EUSOL vs. PDGF Dressing for Diabetic Foot Ulcers

Services Hospital, Lahore

Status: Completed

Conditions: Diabetic Wound

Treatments: Procedure: EUSOL Dressing; Procedure: Platelet-Derived Growth Factor (PDGF) Dressing

Study type: Interventional

Funder types: Other

Identifiers

NCT07493343

RCT28SIMS

Details and patient eligibility

About

Diabetic foot ulcers are a major cause of morbidity and amputation. This randomized controlled trial will compare the efficacy of a traditional antiseptic dressing (EUSOL) with a modern biologic dressing containing Platelet-Derived Growth Factor (PDGF) in promoting wound contraction. The study aims to determine if PDGF dressing leads to better healing outcomes in patients with Grade II Wagner diabetic foot ulcers.

Enrollment: 120 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of diabetes mellitus.
• Presence of a Grade II Wagner diabetic foot ulcer (penetrating to subcutaneous tissue, without involvement of tendon, bone, or joint).
• Ulcer size less than 6 x 6 cm at baseline.

Exclusion criteria

• Uncontrolled diabetes
• Malnourished (BMI less than 20)
• HB less than 10
• ABPI less than 0.9
• Immunosuppression therapy
• Patients with malignancy or uncontrolled cardiopulmonary, neurological, or psychiatric disease.
• Severe active infection

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

EUSOL Group

Active Comparator group

Treatment:

Procedure: EUSOL Dressing

PDGF Group

Active Comparator group

Treatment:

Procedure: Platelet-Derived Growth Factor (PDGF) Dressing