The Impact of Zinc and Probiotics in Preventing Pediatric Antibiotic-Associated Diarrhea in Southern Iran (AAD)

Hormozgan University of Medical Sciences

Status: Completed

Conditions: Diarrhea; Antibiotic-associated Diarrhea

Treatments: Dietary Supplement: Zinc Supplement, probiotic

Study type: Interventional

Funder types: Other

Identifiers

NCT06665503

IR.HUMS.REC.1399.579

Hormozgan University (Other Identifier)

Details and patient eligibility

About

The Impact of Zinc and Probiotics in Preventing Pediatric Antibiotic-Associated Diarrhea in Southern Iran

Full description

The participants will be children aged 3 months to 3 years.The zinc group received oral zinc supplementation; 2.5 ml every 12 hours for children aged <1 year and 5 ml every 12 hours for older children; the probiotics group received oral probiotics; 1 probiotic sachet; and the control group received nothing.

Enrollment: 165 patients

Sex: All

Ages: 3 months to 3 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. children aged 3 months to 3 years
2. prescribed antibiotics for various medical conditions

Exclusion criteria

1. Diarrhea, Dysentery
2. Underlying chronic disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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165 participants in 3 patient groups

65 children in cotrol group

No Intervention group

Description:

Only standard medication.

65 children in Zinc group

Experimental group

Description:

The zinc group received oral zinc supplementation; 2.5 ml every 12 hours for children aged \<1 year and 5 ml every 12 hours for older children.

Treatment:

Dietary Supplement: Zinc Supplement, probiotic

65 children in Probiotic group

Experimental group

Description:

The probiotics group received oral probiotics; 1 probiotic sachet (KidiLact: Lacticaseibacillus rhamnosus, Lactobacillus reuteri, Lactobacillus acidophilus, Bifidobacterium infantis, Lactobacillus acidophilus, Bifidobacterium bifidum and Streptococcus thermophilus)

Treatment:

Dietary Supplement: Zinc Supplement, probiotic