Evaluate Oral Topotecan With HM30181A Monotherapy in Patients With Advanced Malignancies

Athenex

Status and phase

Completed

Phase 1

Conditions

Solid Tumor

Treatments

Drug: Oratopo

Study type

Interventional

Funder types

Industry

Identifiers

NCT03987685

KX-ORATOP-001

Details and patient eligibility

About

This is a multicenter, nonrandomized, open-label, safety, tolerability and pharmacokinetic (PK) study to determine the MTD and optimal dosing of Oratopo. No control group has been included.

Full description

This is a multicenter, open-label, safety, tolerability, pharmacokinetic, and activity study. Eligible subjects will be adults with advanced solid tumor malignancies. In the treatment period groups of 3 to 6 subjects will receive a single dose of oral Oratopo will be administered and will be followed for toxicity. Dose escalation will continue until an MTD is reached, or nonlinear increases in exposure are confirmed, or a maximum dose of Oratopo is reached.

Enrollment

10 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Signed written informed consent
Male and female adults ≥18 years of age
Histologically or cytologically confirmed solid tumor that is metastatic or unresectable and for which standard curative or palliative measures do not exist or are no longer effective
Topotecan monotherapy is a reasonable treatment in the judgement of the Investigator
Measurable disease as per RECIST v1.1 criteria
Able to swallow oral medication as an intact dosage form
Adequate hematologic status as demonstrated by not requiring transfusion support or granulocyte colony-stimulating factor (G-CSF)levels maintained
Adequate liver function.
Adequate renal function
Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1
Life expectancy of at least 3 months
Females must be postmenopausal (>12 months without menses) or surgically sterile (ie, by hysterectomy and/or bilateral oophorectomy) or, if sexually active, must be using effective contraception (ie, oral contraceptives, intrauterine device, double barrier method of condom and spermicide) and agree to continue use of contraception for 30 days after their last dose of study drug.
Sexually active male patients must use a barrier method of contraception during the study and agree to continue the use of male contraception for at least 30 days after the last dose of study drug.

Exclusion criteria

Currently taking a prohibited concomitant medication, other than a premedication, that are Strong inhibitors or strong inducers of cytochrome P450
Unresolved toxicity from prior chemotherapy
Planning to receive other medical, surgical, or radiological cancer treatments during the course of this study
Received investigational agents within 14 days or 5 half-lives prior to the first study dosing day, whichever is longer
Require therapeutic use of anticoagulants.
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, clinically significant myocardial infarction unstable angina pectoris, clinically significant cardiac arrhythmia, bleeding disorder, chronic pulmonary disease requiring oxygen, or psychiatric illness/social situations that would limit compliance with study requirements.
Major surgery to the upper GI tract
Hypersensitivity to topotecan or allergy to HM30181A or its excipients.
Any other condition which the Investigator believes would make participation in the study not acceptable