Evaluating Cardiovascular Phenotypes Using Induced Pluripotent Stem Cells (iPSC)

Scripps Translational Science Institute

Status: Invitation-only

Conditions: Coronary Artery Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01517425

11-5676

Details and patient eligibility

About

This research is being done to understand how changes in DNA may put people at risk for developing coronary artery disease. Stem cells will be made using cells from blood and/or skin biopsy samples. We are trying to understand which specific changes in DNA negatively impact a person's health.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Cases:

1. Previously enrolled in the CAD module of the Genebank at Scripps Clinic Registry
2. Eligible to have their blood drawn
3. Be reliable, cooperative and willing to comply with all protocol-specified procedures
4. Able to understand and grant informed consent

Controls:

1. Previously enrolled in the Healthy Elderly Active Longevity (HEAL) Cohort
2. Eligible to have their blood drawn
3. Be reliable, cooperative and willing to comply with all protocol-specified procedures
4. Able to understand and grant informed consent

Exclusion criteria

1. Unwilling or unable to grant informed consent.
2. Have a significant medical condition that in the Investigator's opinion may interfere with subject's study participation.

Trial design

200 participants in 2 patient groups

Cases

Description:

Subjects previously enrolled in the Scripps Genebank Study

Controls

Description:

Subjects previously enrolled in the Scripps Healthy Elderly Active Longevity (HEAL) Cohort