Evaluating Clinical Evaluation Tools for Predicting Risk of Complications After Hematopoietic Stem Cell Transplant

Mayo Clinic

Status: Completed

Conditions: Malignant Solid Neoplasm; Hematopoietic and Lymphoid System Neoplasm

Treatments: Other: Electronic Health Record Review; Other: Clinical Evaluation

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT05766332

21-000913 (Other Identifier)

NCI-2022-01589 (Registry Identifier)

Details and patient eligibility

About

This study evaluates whether clinical evaluation tools such as the six-minute walk test, hand grip strength test, and gait speed test, are useful in predicting risk of complications in patients undergoing hematopoietic stem cell transplants (HCT). Being able to predict who is at increased risk of post-HCT complications can help better inform patients and providers on the risks and benefits of undergoing HCT and determine whether certain patients should have closer post-HCT monitoring due to an increased risk of complications.

Full description

PRIMARY OBJECTIVE:

I. To develop novel pre-transplant tools for determining risk of post-HCT pulmonary complications.

OUTLINE: This is an observational study.

Patients undergo a clinical evaluation consisting of a six-minute walk test, hand grip strength test, and gait speed test on study. Patients' medical records are also reviewed for a year on study.

Enrollment: 137 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients (age >= 18 years old)
• Undergoing evaluation for autologous or allogeneic bone marrow transplant (HCT) at Mayo Clinic Rochester
• Scheduled for pre-HCT pulmonary function test by the primary team

Exclusion criteria

• Limited mobility requiring use of gait aid or wheelchair
• Fall risk

Trial design

137 participants in 1 patient group

Observational (clinical evaluation, record review)

Description:

Patients undergo a clinical evaluation consisting of a six-minute walk test, hand grip strength test, and gait speed test on study. Patients' medical records are also reviewed for a year on study.

Treatment:

Other: Electronic Health Record Review

Other: Clinical Evaluation