Evaluating of Role of Myeloperoxidase in Prediction of Outcomes of Cardiac Surgery Procedures. (MPO-CSP)

St. Petersburg State Pavlov Medical University

Status: Enrolling

Conditions: Cardiac Procedure Complication; Ischemic Heart Disease; Valve Heart Disease; Defect Septal

Treatments: Other: Valve Repair Procedure with CABG.; Other: Pump-assisted CABG; Other: Valve Repair Procedure without CABG.; Other: Off-pump CABG; Other: On-pump CABG

Study type: Interventional

Funder types: Other

Identifiers

NCT03786965

№22/18-H

Details and patient eligibility

About

The main objection is to investigate molecular biology of myocardial damage during cardiac surgery procedures.

Full description

To assess outcomes after cardiac surgery procedures. To investigate serum level of myeloperoxidase, morphology of left atrium appendage, to perform genetic analysis and cell biology.

Enrollment: 2,000 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• ischemic heart disease with indications for operation
• valve disease with indications for operation
• ischemic heart disease combined with valve disease with indications for operation

Exclusion criteria

• patient refusal

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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2,000 participants in 5 patient groups

On-pump CABG.

Other group

Description:

On-pump CABG.

Treatment:

Other: On-pump CABG

Off-pump CABG.

Other group

Description:

Off-pump CABG.

Treatment:

Other: Off-pump CABG

Pump-assisted CABG.

Other group

Description:

Pump-assisted CABG.

Treatment:

Other: Pump-assisted CABG

Heart Valve Procedure without CABG.

Other group

Description:

Heart Valve Procedure without CABG.

Treatment:

Other: Valve Repair Procedure without CABG.

Heart Valve Procedure with CABG.

Other group

Description:

Heart Valve Procedure with CABG.

Treatment:

Other: Valve Repair Procedure with CABG.