Evaluating of the Impact of Micronutrient Interventions Among Adolescents in Mozambique

World Vision US

Status: Completed

Conditions: Anemia

Treatments: Behavioral: Adolescent Nutrition Curriculum; Dietary Supplement: Iron Folic Acid Supplementation; Dietary Supplement: Multiple micronutrient supplementation

Study type: Interventional

Funder types: Other

Identifiers

NCT06815315

218961 (Other Grant/Funding Number)

WorldVision

Details and patient eligibility

About

This purpose of this study is to assess effects of iron and folic acid supplementation and multiple micronutrient supplementation on anemia status and the impact of a nutrition curriculum on diet diversity and anemia knowledge among adolescent girls.

Full description

This study aimed to implement and evaluate micronutrient supplementation interventions to improve adolescent nutrition, health, and education in Mozambique. In conjunction with the Mozambique Ministries of Health, Education and Culture, we conducted a two-arm cluster-randomized trial in three secondary schools, enrolling 28 girls' clubs (14 per arm). Each club was comprised of around 18 girls aged 13 to 20 years. Using constrained sampling to balance for age and school, clubs were randomly assigned to one of two intervention groups: 1) Multiple Micronutrient Supplementation (MMS) for five months plus a Nutrition Curriculum, or 2) Iron and Folic Acid Supplementation (IFAS) plus a Nutrition Curriculum. Girls enrolled in the MMS arm consumed supplements daily for 4 months at home and weekly nutrition messages delivered through the clubs. Girls enrolled in the IFAS arm consumed supplements once a week for 4 months at school (the standard of care) and weekly nutrition messages delivered through the clubs. The study evaluated the effects of MMS and IFAS on anemia status and the impact of the nutrition curriculum on diet diversity and anemia knowledge.

Enrollment: 490 patients

Sex: Female

Ages: 13 to 20 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Adolescents aged 13-20 years Enrolled in secondary school at study initiation Member of an IMPACT+ Girls Club at one of the participating schools Consent provided by the parent Assent provided by the adolescent

Exclusion criteria

No informed consent from parent or assent from adolescent Self-reported pregnancy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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490 participants in 2 patient groups

Multiple Micronutrient Supplementation (MMS) Arm

Active Comparator group

Description:

The adolescent girls randomly assigned to the MMS arm consumed MMS for four months and participated in girls' clubs where they received nutrition messages.

Treatment:

Dietary Supplement: Multiple micronutrient supplementation

Behavioral: Adolescent Nutrition Curriculum

Iron Folic Acid Supplementation (IFAS) Arm

Active Comparator group

Description:

The adolescent girls randomly assigned to the IFAS arm consumed IFAS for four months and participated in girls' clubs where they received nutrition messages

Treatment:

Dietary Supplement: Iron Folic Acid Supplementation

Behavioral: Adolescent Nutrition Curriculum