Evaluating Oxidative Stress in Menopause

Sisli Hamidiye Etfal Training and Research Hospital

Status: Completed

Conditions: Menopause; Oxidative Stress

Treatments: Other: Thiol disulfide level

Study type: Observational

Funder types: Other

Identifiers

NCT04624386

menopausethiol

Details and patient eligibility

About

Thiol disulfide levels will be determined using venous blood samples from pre- and postmenopausal women to evaluate oxidative stress in menopause. Furthermore, oxidative stress will be assessed according to age, and years since the start of menopause. Also, whether the presence of menopause related osteoporosis has any association with oxidative stress will be determined.

Full description

A total of 77 subjects are divided into two groups: study group (postmenopausal women) and control group premenopausal women). Biometric data such as age, bmi, obstetric anamnesis, history of komorbidities, PAP smear results are recorded. Mammography results, dexa scores of post menopausal women are also obtained. Venous blood samples from all subjects are collected. Thiol disulfide levels will be determined from serum samples. Thiol disulfide levels will first be compared between the study and the control group in order to determine the oxidative stress in menopause. In secondary evaluation years of menopause, age, and dexa scores will be included.

Enrollment: 77 patients

Sex: Female

Ages: 30 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Women who entered menopause as a natural process Women within the age limits Still menstruating healthy women as control subjects

Exclusion criteria

Women who have entered menopause prematurely Women who have entered menopause following a surgery Women with medically induced menopause Women without any autoimmune or chronic inflammatory diseases Women who are taking hormone replacement therapy due to menopausal symptoms Women without any malignant diseases

Trial design

77 participants in 2 patient groups

Postmenopausal/Study

Description:

Women older than 45 years of age and who have not had any menstruation for the past 12 months are considered as having entered menopause. These women are included in this group.

Treatment:

Other: Thiol disulfide level

Premenopausal/Control

Description:

Healthy women who are still having regular menstruations are included in this group

Treatment:

Other: Thiol disulfide level