Evaluating the Effect of Chronic Antihypertensive Therapy on Vasopressor Dosing in Septic Shock

Rush

Status: Completed

Conditions: Septic Shock

Study type: Observational

Funder types: Other

Identifiers

NCT02884011

16081001

Details and patient eligibility

About

Retrospective study to examine the effects of chronic antihypertensive medications on vasopressor dosing in septic shock

Full description

This will be a retrospective four-cohort study. The four cohorts will be septic shock patients that were: 1) not on either a chronic β-blocker or chronic angiotensin-converting-enzyme inhibitor (ACE-Inhibitor), 2) on chronic β-blocker, 3) on ACE-Inhibitor, and 4) on both chronic β-blocker and ACE-inhibitor

Enrollment: 133 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients 18 years of age or older
• Diagnosis of septic shock requiring vasopressor therapy (norepinephrine, epinephrine, phenylephrine, dopamine, or vasopressin)
• Admitted to an intensive care unit (ICU) at Rush University Medical Center (RUMC)
• Time frame: 01/01/2012 to 07/1/2016

Exclusion criteria

• Pregnant patients
• Transfer from outside hospital on vasopressors
• Admitted in cardiopulmonary arrest
• Prior arrest within 24 hours of admission to RUMC

Trial design

133 participants in 4 patient groups

No chronic antihypertensives

Description:

not on either a chronic β-blocker or ACE-Inhibitor

β-blocker

Description:

on chronic β-blocker

ACE-Inhibitor

Description:

on chronic ACE-Inhibitor

Both β-blocker and ACE-inhibitor

Description:

on both chronic β-blocker and ACE-inhibitor