Evaluating the Effect of Oxygentherapy on Concentration at Chronic Lung Patients

University of Aarhus

Status: Completed

Conditions: Lung Diseases, Interstitial; Pulmonary Disease, Chronic Obstructive

Treatments: Other: oxygen therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT02125916

Driving simulation COLD & ILD

Details and patient eligibility

About

The objective is to study the cognitive functions in patients with chronic obstructive lung disease (COLD) and patients with interstitial lung disease (ILD) compared to healthy controls. The cognitive functions are tested with and without oxygen therapy to clarify the effect of oxygen therapy. Driving simulations is used to test the cognitive functions.

The hypothesis is that patients with chronic lung disease have decreased cognitive functions and that oxygen therapy will increase their cognitive functions.

Enrollment: 32 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• COLD with forced expiratory volume at one second (FEV1) <50%, without long term oxygen therapy
• COLD with FEV1 <50%, with long term oxygen therapy
• ILD with diffusion capacity of lung for carbon monoxide (DLCO) < 50%, without long term oxygen therapy

Exclusion criteria

• comorbidity which decreases cognitive function
• comorbidity which decreases concentration
• physical comorbidity which makes it impossible to complete the test

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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32 participants in 4 patient groups

COLD without long term oxygen therapy

Experimental group

Description:

Driving in the simulator two times, one time with and one time without oxygen therapy

Treatment:

Other: oxygen therapy

COLD with long term oxygen therapy

Experimental group

Description:

Driving in the simulator two times, one time with and one time without oxygen therapy

Treatment:

Other: oxygen therapy

ILD without long term oxygen therapy

Experimental group

Description:

Driving in the simulator two times, one time with and one time without oxygen therapy

Treatment:

Other: oxygen therapy

Controls

No Intervention group

Description:

Driving in the simulator one time without oxygen therapy