Evaluating the Effect of Senna in Uremic Pruritus

Shiraz University of Medical Sciences

Status: Completed

Conditions: End Stage Renal Disease; Pruritus

Treatments: Drug: Senna; Drug: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT02008864

Senna in Uremic Pruritus

Details and patient eligibility

About

Uremic pruritus remains one of the most frustrating and potentially disabling symptoms in patients with end stage renal disease. It affect up to 90 percent of patients with end stage renal disease. Several hypotheses have been postulated for the possible underlying etiology, but none is conclusive. Aside from kidney transplantation, which is only definitive treatment, therapeutic approaches have largely been empirical, and no firm evident-base treatments are available. The main goal of therapy remains to minimize severity of pruritus. In Iranian traditional medicine Cassia senna L. is used for healing uremic pruritus . In this study investigators considered to evaluate effect of Cassia senna L. in uremic pruritus by a double blind placebo control clinical trial. It is hypothesized that oral Cassia senna L. may attenuate uremic pruritus by decreasing serum IL-2, IFN-γ and TNF-α.

Enrollment: 60 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hemodialysis patients
• Suffering from pruritus for at least 6 weeks
• Have not responded to other drugs

Exclusion criteria

• Dermatological disease
• Liver disease
• Metabolic disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Wheat

Treatment:

Drug: Placebo

Senna

Active Comparator group

Description:

Senna

Treatment:

Drug: Senna