Evaluating the Efficacy and Safety of AI Localization Models in Multidisciplinary Team Care for NSCLC

Wen-zhao ZHONG

Status: Enrolling

Conditions: Nonsmall Cell Lung Cancer

Treatments: Diagnostic Test: Treat Regimen

Study type: Interventional

Funder types: Other

Identifiers

NCT07626736

KY2025-1003-02

Details and patient eligibility

About

The goal of this clinical trial is to evaluate the effectiveness and safety of a locally deployed artificial intelligence (AI) decision-support model in the multidisciplinary team (MDT) process for patients with non-small cell lung cancer (NSCLC).

The main questions it aims to answer :

What is the level of agreement between treatment recommendations generated by the AI model and those made by a traditional MDT? How often do clinicians modify their final treatment decision after reviewing the AI model's recommendation? Researchers will compare treatment plans from the traditional MDT (Arm 1), the AI model (Arm 2), and the clinician's final decision after reviewing the AI output (Arm 3) to assess consistency, decision modification rates, and clinical efficiency.

Participants will:

Have their clinical, imaging, and molecular data submitted to both the traditional MDT and the AI model for independent treatment recommendations Receive a final treatment plan determined by clinicians after reviewing both recommendations, with follow-up for safety and survival outcomes

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age ≥ 18 years;
2. MDT (Multidisciplinary Team) discussion deems a systemic treatment plan necessary;
3. Complete clinical, imaging, and molecular pathological data.

Exclusion criteria

1. Stage I patients;
2. Diagnosed with a thoracic tumor other than NSCLC;
3. Lack of detailed medical data, or missing data;

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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300 participants in 1 patient group

AI-Assisted Multidisciplinary Team Decision-Making for Non-Small Cell Lung Cancer

Experimental group

Treatment:

Diagnostic Test: Treat Regimen