Evaluating the Impact of Quitting Using Executive Function Strategy Training (QUEST) on Smoking Cessation in Homeless Young Adult Smokers

The Ohio State University

Status

Completed

Conditions

Cigarette Smoking-Related Carcinoma

Treatments

Behavioral: Smoking Cessation Intervention

Drug: Nicotine Replacement

Other: Tobacco Cessation Counseling

Other: Survey Administration

Procedure: Biospecimen Collection

Procedure: Cognitive Assessment

Other: Interview

Study type

Interventional

Funder types

Other

Identifiers

NCT06745154

NCI-2024-04793 (Registry Identifier)

OSU-23119

Details and patient eligibility

About

This clinical trial evaluates the impact of Quitting Using Executive Function Strategy Training (QUEST) on quitting smoking (cessation) in homeless young adult smokers with an acquired brain injury (ABI). Over 70% of youth and young adults experiencing homelessness (YYEH) smoke tobacco. More than half of YYEH who smoke have made at least one attempt to quit smoking but few use evidence-based methods to increase success. In addition, 9 out of 10 of these have an acquired brain injury which may have a negative impact on successful smoking cessation. QUEST may help homeless young adult smokers with an ABI quit smoking.

Full description

PRIMARY OBJECTIVES:

I. Gather data needed to build QUEST (Quitting Using Executive function Strategy Training), an intervention to help youth and young adults (YYEH) with executive function dysregulation better 1) access evidence-based cessation; 2) adhere to processes of evidence-based treatment; and 3) address stress to prevent relapse.

II. Establish the feasibility of collecting acquired brain injury (ABI) status, and impact data sensitive to change over time (clinical and epigenetic), from YYEH tobacco users in community settings.

EXPLORATORY OBJECTIVE:

I. Determine if 1) executive functioning 2) mild cognitive impairment and 3) epigenetic age & other biomarkers of health risk measures are sensitive to difference by ABI status among YYEH past week combustible tobacco users.

OUTLINE:

Patients receive access to the Ohio Tobacco Quitline, receive nicotine patches, gum, or lozenges for up to 8 weeks. Patients also participate in tobacco cessation counseling sessions for 5 sessions over 8 weeks. Patients additionally undergo cognitive assessment and nasal swab collection on study.

Enrollment

27 patients

Sex

All

Ages

18 to 24 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

18-24 years old
Utilizing STAR House ( a drop-in center for youth and young adults experiencing homelessness) services
Use of combustible tobacco product in the last week
Willing to quit smoking in the next 30 days
Acquired Brain Injury (ABI) (15 youth with and 15 without)
- CHATS will be used to determine ABI. Ask "C", "H" and "A" of the CHATS tool. If yes to C OR H and yes to A, that will be considered positive for ABI
Have access to a phone
Willing to use phone for QuitLine (QL) services
Willing to enroll in Ohio Tobacco Quit Line
Willing to share Ohio Tobacco Quit Line portal data with researchers
Willing to provide biospecimens (exhaled air and nasal samples)
Conversational English skills