Evaluating the Role of Intra-articular Injections of Platelet Rich Plasma (PRP) in Patients With Rheumatoid Arthritis.

Dalia Salah Saif

Status: Unknown

Conditions: RA - Rheumatoid Arthritis

Treatments: Procedure: PRP intra articular injection; Procedure: NACL intra articular injection

Study type: Interventional

Funder types: Other

Identifiers

NCT04264494

1475 (Other Identifier)

Details and patient eligibility

About

To evaluate the therapeutic effect of 3 local doses of PRP intra-articular injection in patients with RA regarding the improvement of disease activity and quality of life versus placebo.

Full description

100 patients with RA fulfilling the 2010 ACR-EULAR classification criteria for RA were recruited from the outpatient clinic of the Rheumatology and Rehabilitation department. All patients were subjected to clinical and laboratory assessment, visual analog score (VAS) scale and Health Assessment Questionnaire (HAQ). Fifty patients were injected intra-articularly with 3 doses of PRP and 50 patients who serve as a control injected with 3 doses of placebo at 4 weeks intervals for the tender joints and revaluated at 1, 3 months post the last injection regarding the same evaluating tools.

Enrollment: 100 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients diagnosed as RA regarding 2010 new criteria of RA, both sex,aged20-60 years old.

Exclusion criteria

• Patients with Local abscess,
• systemic illness as (diabetes mellitus, malignancy),
• patients on opioids analgesics.
• pregnancy, blood disorders(coagulopathy, thrombocytopenia),

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups, including a placebo group

PRP group

Experimental group

Description:

Fifty RA patients were injected intra-articularly with 3 doses of PRP in their joints

Treatment:

Procedure: PRP intra articular injection

placebo group

Placebo Comparator group

Description:

Fifty RA patients were injected intra-articularly with 3 doses of saline in their joints.

Treatment:

Procedure: NACL intra articular injection