Evaluation and Comparison of the Growth Rate of Pancreatic Cancer Patient-derived Organoids

Technical University of Munich

Status: Unknown

Conditions: Pancreas Cancer

Treatments: Procedure: FNA, FNB

Study type: Interventional

Funder types: Other

Identifiers

NCT03990675

Pancreatic cancer organoids

Details and patient eligibility

About

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive forms of cancer. Despite advances in the understanding of the mechanisms underlying PDAC pathogenesis, the impact on patient benefit is lagging. As a result, new model systems are being developed and used to fill this gap with the hope of translation into improved diagnostics and therapeutics.

Organoids represent a powerful tool for research with the capacity to be applied to many key aspects of pancreatic tissue pathology.

3D organoids can be generated from endoscopic fine-needle aspiration or fine needle biopsy samples. In this study, we will evaluate and compare the growth rate of pancreatic cancer patient-derived organoids generated from matched fine needle Aspirations (FNA) and fine needle biopsies (FNB).

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with indication for EUS-guided FNA or FNB of a suspected pancreatic malignancy

Exclusion criteria

• < 18 years
• patients unable to give consent

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

50 participants in 1 patient group

FNA, FNB

Experimental group

Treatment:

Procedure: FNA, FNB