Evaluation and Correlation of Serum Fetuin-A Levels in Periodontal Health and Disease: A Clinico-biochemical Study


Krishnadevaraya College of Dental Sciences & Hospital




Gingivitis and Periodontal Diseases


Procedure: Non surgical periodontal therapy

Study type


Funder types




Details and patient eligibility


The present clinico-biochemical study was carried out to estimate the levels of Fetuin A and MMP7 in serum of systemically healthy subjects in periodontal health and disease and to evaluate the impact of periodontal interventional therapy (scaling and root planing) on the same.

Full description

Sixty sex-matched subjects (30 males and 30 females) belonging to a common age group (30-39 yrs) were enrolled for the study to eliminate bias from confounding factors. They were divided into three groups consisting of 20 subjects in each group based on the clinical and radiological parameters; Periodontally healthy (Group I), Chronic gingivitis (Group II) and chronic periodontitis ( Group IIIa) from whom serum samples were collected. The Group IIIb further comprised of the subjects from Group IIIa, who had received non-surgical periodontal therapy (scaling and root planing). Serum samples were collected at baseline and at 12 weeks post therapy. Fetuin A and MMP-7 concentration was determined from serum samples of patients using ELISA. The results of our study depicted that Fetuin A concentration negatively correlates, whereas, MMP7 positively correlates with the extent of periodontal inflammation. Further, Periodontal therapy demonstrated a significant increase in serum Fetuin A and decrease in MMP 7 levels establishing the influence of periodontal therapy in stabilizing their levels.


60 patients




30 to 39 years old


Accepts Healthy Volunteers

Inclusion criteria

  • Age group of 30-39 years.
  • Systemically healthy subjects.
  • Patient who are co-operative and able to attend follow up.
  • Patient who have not received any periodontal treatment within the past six months of baseline examination.
  • Dentition with at least 20 functional teeth.

Exclusion criteria

  • Medically compromised patients (history of diabetes mellitus, liver diseases, cardiovascular disease, kidney diseases, rheumatoid arthritis, bone diseases pulmonary disease, viral and fungal infections).
  • Patients with calcification disorders (chronic kidney disease with vascular calcification, hyperparathyroidism, excessive intake of vitamin D, valvular calcific aortic stenosis
  • Aggressive periodontitis.
  • Bleeding disorders
  • Gross oral pathology and suppuration
  • Patients who had received antibiotic therapy and anti inflammatory within the last six months.
  • Anomalies of the immune system.
  • Pregnancy and lactation.

Trial design

60 participants in 3 patient groups

No Intervention group
Ten patients with clinically healthy gingiva with probing depth less than 3mm and less than or equal to 10% sites with gingival bleeding on probing present.
chronic gingivitis
No Intervention group
Chronic gingivitis was defined as having probing depth (PD) less than or equal to 4mm, relative attachment loss (RAL) ) less than or equal to 3mm and more than to 25% sites with gingival bleeding present (BOP)
chronic periodontitis
Active Comparator group
Chronic periodontitis was defined as having probing depth more than or equal to 5mm, RAL more than or equal to 8mm, with more than or equal to 10% sites with BOP positive and evidence of bone loss determined radiographically. Non surgical periodontal therapy (SRP) was concluded in 3 months. Within the duration of the study, all subjects received supportive therapy
Procedure: Non surgical periodontal therapy

Trial contacts and locations



Data sourced from clinicaltrials.gov

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