Evaluation and Importance of the PD-1/PD-L1 and the IL-10/IL-10R Axis in Malignant and Benign Pleural Effusions - a Pilot Study

University of Vienna

Status: Unknown

Conditions: Pleural Effusion

Treatments: Diagnostic Test: Pleural effusion will be examined for various cytokines and PD1-lymphocytes.

Study type: Observational

Funder types: Other

Identifiers

NCT04834830

Version 1.1 26.01.2021

Details and patient eligibility

About

The aim of this study is to evaluate the concentrations of interleukin-2, interleukin-10, interferon-gamma, PD1+ lymphocytes, and the interleukin-10 receptor expression in malignant and benign effusions.

Full description

In this prospective trial, 80 patients with pleural effusions and indication for thoracocentesis, drainage, indwelling pleural catheter (IPC) management and/or video-assisted thoracoscopic surgery are enrolled. The pleural effusion will be examined for different cytokines, cytokine-receptors, PD1-lymphocytes and CD4+/CD25+/Foxp3+ regulatory T cell.

Enrollment: 80 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age >18 years
• radiologically confirmed pleural effusion with an indication for puncture, pleural drain insertion, or video-assisted thoracoscopy for diagnostic and/or therapeutic reasons
• Signed declaration of consent

Exclusion criteria

• Withdrawal or cessation of participation

Trial design

80 participants in 1 patient group

Patients with pleural effusion

Description:

In patients with pleural effusion and indication for diagnostic and/or therapeutic procedures (thoracocentesis, drainage of fluid, indwelling pleural catheter (IPC) management, and/or video-assisted thoracoscopic surgery), pleural fluid will be examined for various cytokines and PD1-lymphoctyes.

Treatment:

Diagnostic Test: Pleural effusion will be examined for various cytokines and PD1-lymphocytes.