Evaluation And Risk Assessment For Persistent Postsurgical Pain After Breast Surgery (B-CAPP)

KK Women's and Children's Hospital

Status: Active, not recruiting

Conditions: Breast Cancer; Depression, Anxiety; Chronic Pain; Acute Pain

Treatments: Other: Mechanical Temporal Summation assessment; Other: Questionnaires; Other: Pain threshold assessment

Study type: Observational

Funder types: Other

Identifiers

NCT03408717

2017/2805

Details and patient eligibility

About

Pre-existing pain and severe postoperative pain are predictors of persistent pain after surgery, but a complete understanding on the development of persistent pain is still lacking. The study aims to identify clinically relevant and genetic risk factors for persistent postsurgical pain that can be reliably distinguished statistically.

Full description

The study will focus on: (i) risk factors representing biopsychosocial processes that influence chronic pain, such as pain and psychological vulnerability; (ii) genetic factors relating to mechanistic pathways to persistent pain generation. Patients will be recruited from those undergoing breast cancer surgery at the mentioned site. Pain and anxiety assessment will be conducted via visual analogue scoring, mechanical temporal summation assessment and a series of questionnaires. After the surgery, all patients will be given appropriate analgesia, and the pain score and analgesia usage will be recorded. Phone survey will be conducted 4 and 6 months, respectively, after surgery to determine the outcomes.

Enrollment: 220 estimated patients

Sex: Female

Ages: 21 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged between 21 - 80 year old;
• Healthy and/or have systemic medical conditions as reviewed by anaesthetist for surgery (ASA 1-3);
• Undergoing breast cancer surgery.

Exclusion criteria

• History of intravenous drug or opioid abuse;
• Current chronic daily treatment with corticosteroids (excluding inhaled steroids);
• Previous history of chronic pain syndrome;
• Obstetric patients.

Trial design

220 participants in 1 patient group

Persistent post surgical pain (PPSP)

Description:

Questionnaires, Mechanical Temporal Summation assessment and pain threshold assessment will be assigned to patient. Within this cohort, some patients will have high pain score recorded (persistent pain) during the follow-up evaluations at 4 and 6 months.

Treatment:

Other: Pain threshold assessment

Other: Questionnaires

Other: Mechanical Temporal Summation assessment