Evaluation by HR-pQCT of Bone Microarchitecture Changes in Patients With Rheumatoid Arthritis Under Anti-TNF Therapy.

Centre Hospitalier Universitaire de Saint Etienne

Status: Terminated

Conditions: Rheumatoid Arthritis

Treatments: Device: HR-pQCT

Study type: Interventional

Funder types: Other

Identifiers

NCT02526992

2008-006256-22 (EudraCT Number)

0701104

A81070-40 (Other Identifier)

Details and patient eligibility

About

Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease in adults and is characterized by chronic inflammation of the joints leading to their destruction, resulting in a major loss of function.

The investigators propose a pilot study for studying changes in bone microarchitecture with High Resolution peripheral micro Computerized Tomography (HR-pQCT) in patients with RA treated with anti-TNF(Tumor Necrosis Factor), with the measurement of micro-architectural parameters in subchondral area near an inflammatory joint during the first 12 months of initiation of an anti-TNF therapy (Infliximab®, Etanercept®, Adalimumab®).

Enrollment: 14 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Men from 18 to 65 years old
• Women from 18 years old to menopause
• Patient with a polyarthritis rheumatoid no controlled by the usual treatment (DAS28>3)
• Patient affiliated or beneficiary of a national insurance system
• Patient with signed consent

Exclusion criteria

• Concomitant osseous disease (Paget's disease, osteomalacia...)
• Endocrinopathy defined on biological criteria (Cushing's disease, hyperthyroidism, hypogonadism...)
• Patients under protection of justice
• Refusal consent

Trial design

14 participants in 1 patient group

patients with anti-TNF therapy

Other group

Description:

patients with rheumatoid polyarthritis inadequately controlled by a conventional treatment, occurring during the first 12 months of initiation of an anti-TNF therapy

Treatment:

Device: HR-pQCT