Evaluation for Benign and Malignant Pulmonary Ground-glass Nodules Based on MRI Dynamic Contrast Enhanced Imaging

Qianfoshan Hospital

Status: Unknown

Conditions: Pulmonary Nodules

Treatments: Diagnostic Test: MRI scan

Study type: Interventional

Funder types: Other

Identifiers

NCT05067023

QianfoshanH Z

Details and patient eligibility

About

Computed tomography (CT) is critical for the diagnosis of lung nodules as well as for therapeutic management. Repeated CT examinations will raise the issue of the cumulative radiation dose and subsequent risk of cancer, thus pushing the need for imaging techniques using low or no radiation dose. Magnetic Resonance Imagery (MRI) with ultrashort echo time (UTE) pulse sequences with high signal-to-noise and spatial resolution is a promising alternative for lung nodules imaging.The purpose of the study is to evaluate the value of dynamic contrast-enhanced MR imaging (DCE-MRI) to discriminate of malignant from benign lesions.

Full description

Computed tomography (CT) is critical for the diagnosis of lung nodules as well as for therapeutic management. Repeated CT examinations will raise the issue of the cumulative radiation dose and subsequent risk of cancer, thus pushing the need for imaging techniques using low or no radiation dose. Magnetic Resonance Imagery (MRI) with ultrashort echo time (UTE) pulse sequences with high signal-to-noise and spatial resolution is a promising alternative for lung nodules imaging.The purpose of the study is to evaluate the value of DCE-MRI to discriminate of malignant from benign lesions.In this study, the investigators are going to validate the efficacy of the DCE-MRI for diagnosing early lung cancer by comparing results of the pre-surgery MRI imaging with the post-surgery pathology.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Ground-glass pulmonary nodules found by CT scan
• Plan to accept surgery or puncture due to the pulmonary nodules
• Absence of treatment such as chemotherapy or radiotherapy and biopsy
• Adequate renal function to tolerate intravenous gadolinium
• Agree to sign informed consent
• Able to lie still during DCE-MRI

Exclusion criteria

• Fail to understand or agree to sign informed consent
• Implanted pacemaker or cardiac defibrillator
• Contraindications to undergoing MRI
• Uncontrolled intercurrent illness
• Pregnant or breastfeeding

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

MRI scan

Experimental group

Description:

All participants will undergo 1 DCE-MRI scan before surgery or puncture.

Treatment:

Diagnostic Test: MRI scan