Evaluation of 2%Bromelain Gel With 0.2%CHX Gel as Subgingival LDD Following SRP in Stage II/III and Grade B Periodontitis -A RCT

Krishnadevaraya College of Dental Sciences & Hospital

Status and phase: Enrolling; Phase 1

Conditions: Periodontal Pocket

Treatments: Procedure: SRP; Drug: Bromelain gel; Drug: chlorhexidine gel

Study type: Interventional

Funder types: Other

Identifiers

NCT06505759

02-D012-147453

Details and patient eligibility

About

The current study is a prospective randomised study Evaluation of 2%Bromelain Gel With 0.2%Chlorhexidine Gel as Subgingival Local Drug Delivery Following Scaling and Root Planing in Stage II/III and Grade B Periodontitis

Full description

36 sites with periodontal pocket depth measuring 4-6mm were selected. The sites selected were divided into

1. Group I (Control)- 12 sites with Probing depth of ≥5mm treated with scaling and root planing alone.
2. Group II -12 sites with Probing depth of ≥5mm treated with scaling and root planing followed by placement of bromelain gel.
3. Group III -12 sites with Probing depth of ≥5mm treated with scaling and root planing followed by placement of chlorhexidine gel.

periodontal pack was placed and patient was recalled at 1week,4th week and 12th week

Enrollment: 36 estimated patients

Sex: All

Ages: 30 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient with have chronic periodontitis in the age group between 30-50 years.

• Patients having ≥20 teeth.

  -.Patients with radiographic evidence of bone loss in atleast two teeth.

• Patients who are systematically healthy.

• Patients with localized pockets with probing depth of ≤ 5mm.

• Patients who are cooperative and able to attend the hospital for regular follow-up.

Exclusion criteria

• Patients who have received any surgical or nonsurgical therapy during past 6months
• Pregnant or lactating females.
• Use of systemic antibiotics in the past 6 months.
• Patient who are not willing to give a written informed consent

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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36 participants in 3 patient groups

GROUP 1-SRP alone

Active Comparator group

Description:

control group is treated with SRP alone

Treatment:

Procedure: SRP

GROUP 2-0.2% BROMELAIN gel

Experimental group

Description:

test group is treated with bromelain gel

Treatment:

Drug: Bromelain gel

GROUP 3-0.2% CHLORHEXIDINE gel

Active Comparator group

Description:

test group is treated with chlorhexidine gel

Treatment:

Drug: chlorhexidine gel