Evaluation of a LAMP Assay for T. Pallidum. Pertenue (LAMP4YAWS)

London School of Hygiene and Tropical Medicine

Status: Completed

Conditions: Yaws

Treatments: Diagnostic Test: PCR; Diagnostic Test: LAMP

Study type: Observational

Funder types: Other

Identifiers

NCT04753788

LSHTM-21633

Details and patient eligibility

About

This is a diagnostic evaluation comparing the performance of real-time PCR performed at a national reference laboratory and a LAMP assay performed at a regional hospital for the diagnosis of yaws

Enrollment: 563 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Lesion consistent with yaws
• Positive treponemal and non-treponemal antibodies assessed by the DPP Syphilis Screen and Confirm RDT

Exclusion criteria

• Unable to give consent

Trial design

563 participants in 1 patient group

Suspected Yaws Cases

Description:

Individuals with a lesion clinically suspected to be yaws and with evidence of positive treponemal and non-treponemal serology as assessed by point of care lateral flow tests (DPP Syphilis Screen and Confirm, Chembio)

Treatment:

Diagnostic Test: LAMP

Diagnostic Test: PCR