Evaluation of a Novel Horizontal Ridge Augmentation Technique in Dentistry

Semmelweis University

Status: Completed

Conditions: Bone Loss, Alveolar; Bone Augmentation

Treatments: Procedure: Horizontal bone augmentation

Study type: Interventional

Funder types: Other

Identifiers

NCT05612737

HORAUG

Details and patient eligibility

About

This case series aimed to assess the efficacy of a novel horizontal ridge augmentation modality using histomorphometry and Raman spectroscopy. Combinations of "sticky bone" and tenting screws without autologous bone were used as augmentative materials.

Full description

This case series aimed to evaluate the efficacy of the horizontal augmentation technique using the tenting screw technique with "sticky bone." The main aim was to determine whether this method provides similar results to the gold standard GBR or autologous onlay block grafts. In addition, the validity of neglecting autologous graft and its possible substitution with growth factor concentrate were examined. The novelty of this study is that no human histological examination of the described procedure has been conducted previously. It is hypothesized that the "stick bone" containing autologous platelet concentrate can substitute the use of particulate autologous bone graft in these type of procedures. In this prospective case series study five patients were enrolled and treated with the same type of bone augmentation in order to increase the alveolar ridge in the horizontal dimension with the previously mentioned technique. After 5 months of healing a second reentry surgery was performed in order to harvest the bone core for biopsy, to asses the chemical compound composition by Raman spectroscopy in vivo and to place the dental implants at the same time. Newly formed tissues were evaluated clinically during reentry, radiologically by CBCT acquisition, qualitatively and quantitatively by histological processing and physicochemically by means of Raman spectroscopy.

Enrollment: 5 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• one or more missing teeth in the jaw's posterior area, where horizontal bone width is ≤5 mm.
• no deficiency in the vertical dimension.
• The tooth must have been removed ≥4 months before augmentation.
• The patient should understand the nature of the research and be compliant in study-related activities

Exclusion criteria

• pregnancy
• smoking
• uncontrolled diabetes
• systemic diseases or drug consumption affecting bone metabolism, and clinically relevant osteoporosis

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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5 participants in 1 patient group

"Sticky bone" and tenting screw

Experimental group

Treatment:

Procedure: Horizontal bone augmentation