Evaluation of a Short Version Computerized Test for Processing Speed to Detect Cognitive Disorders in HIV+ Patients (NEURACog)

Centre Hospitalier Universitaire de Nice

Status

Completed

Conditions

HIV-1

Treatments

Other: New evaluation of neurocognitive functions

Other: Classic evaluation of neurocognitive functions

Study type

Observational

Funder types

Other

Identifiers

NCT03279835

16-PP-09

Details and patient eligibility

About

The objective of this prospective study is to evaluate the prevalence of neurocognitive impairments in HIV infected patients comparing patients with and without HAART. Recent studies have demonstrated a specific HIV infected patients neurocognitive disorders profile. These cognitive disorders concern primarily information processing speed, memory recall, attentional abilities, work related memory, executive functions, and psychometrical speed. This cognitive profile is similar to another highly documented one, described for another central nervous system disease (CNS): multiple sclerosis. In both CNS diseases, the earliest and most severe disorder is the one related to the information processing speed. For the multiple sclerosis patients, a short cognitive test (SDMT) is actually used not only to identify cognitive disorders presence, but also in order to predict a long term disability worsening. A digital version of this test (CSCT), has recently been developed in order to make this early evaluation easier. We hypothesize that CSCT alteration would also predict HAND, in HIV infected patients. A complete neuropsychological assessment is highly time and personal consuming. This short (approximatively 2 minutes) digital test would be highly helpful to identify patients, who will need a more extensive neuropsychological assessment.

Enrollment

86 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients infected with HIV-1
Patients followed in outpatient service, over 18 years of age

Exclusion criteria

Patients infected with HIV-2
Patients with difficulty understanding the French language
Patients present with progressive opportunistic infection
Patients for whom a change of psychotropic treatment was performed in the last 3 weeks
Patients with drug and / or alcohol addiction
Patients with a history of psychiatric disorder
Patients with stroke, endocarditis or meningoencephalitis with severe neurological sequelae