Evaluation of Acid-base Disorders and Ventilation Settings in Cardiogenic Shock and Post-cardiac Arrest Patients: Comparison With VentilO Algorithm (VentilO CU)

Laval University

Status: Begins enrollment this month

Conditions: Cardiac Arrest (CA); Acid Base Disorder; Mechanical Ventilation; Cardiogenic Shock

Treatments: Other: Initiation of mechanical ventilation

Study type: Observational

Funder types: Other

Identifiers

NCT07484828

2026-4504

Details and patient eligibility

About

This study aims to better understand how mechanical ventilation settings affect patients admitted to the coronary care unit after cardiac arrest or with cardiogenic shock. These patients often require mechanical ventilation, but current guidelines provide limited evidence on the best approach. Improper ventilation settings can lead to acid-base imbalances, such as respiratory acidosis or alkalosis, which may worsen patient outcomes.

The retrospective analysis will include 100 adult patients (50 post-cardiac arrest and 50 with cardiogenic shock) who were mechanically ventilated upon admission. The study has two main objectives:

Determine how often acid-base disorders occur in these patients and describe their characteristics.

Compare the initial ventilator settings chosen by clinicians with those suggested by VentilO, a decision-support algorithm.

The investigators will evaluate the potential effect of the VentilO recommendations on the first arterial (or capillary) blood gases compared to the real settings.

This information will help refine the algorithm and guide future research on improving ventilation strategies for critically ill cardiac patients.

Participation does not involve any intervention, as the study uses existing medical records.

Enrollment: 100 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult (Age >=18 years old)
• Under mechanical ventilation with endotracheal tube for :

post cardiac arrest or cardiogenic shock

- Bood gases result availability up to 4 hours after coronary unit admission

Exclusion criteria

• Lack of patient anthropometric data (height and weight) available in the patient record
• No information in the record regarding the data on the humidification systems used at the time of the first blood gas test upon admission to the coronary care unit.
• Patient stabilzed in other hospital before coronary unit admission or adjustment of respiratory parameters after a blood gas test.

Trial design

100 participants in 2 patient groups

Patient post cardiac arrest

Treatment:

Other: Initiation of mechanical ventilation

Patient with cardiogenic shock

Treatment:

Other: Initiation of mechanical ventilation