Evaluation of Advanced Glycation End-products (AGE) and the Erectile Dysfunction (DE) in Diabetic Patients (APGADEPD)

Centre Hospitalier Universitaire, Amiens

Status: Completed

Conditions: Diabetes Mellitus, Non-Insulin-Dependent; Erectile Dysfunction

Treatments: Other: DE assessment; Other: AGE measurement

Study type: Interventional

Funder types: Other

Identifiers

NCT02770235

PI2013_843_0021

Details and patient eligibility

About

In diabetics there is an abnormally increased production of AGEs due to hyperglycemia. An association was shown between AGE measured by biopsy (invasive) and DE patients with diabetes (increase of AGE level in the corpora cavernosa). To date no studies have explored the link between DE and the measure of AGE by a non-invasive method of Auto-fluorescence (AF) Skin (AGEReaderTM).

If the hypothesis of an association between DE and AGE measured by AF was checked, screening for erectile dysfunction and measurement of AGEs could help to improve the overall management of diabetic patient (including cardiovascular) and their quality of life.

Enrollment: 97 patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diabetes Type 2

Exclusion criteria

• skin hyperpigmentation

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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97 participants in 1 patient group

DE assessment and AGE measurements

Experimental group

Description:

To evaluate the association between erectile dysfunction (DE) and AGE levels by using non-invasive measurement AGE-ReaderTM, in diabetic patients

Treatment:

Other: AGE measurement

Other: DE assessment