Evaluation of Adverse Long-term Effects in Young Adult Survivors of Acute Leukemia (LEA-JA)

Institut Paoli-Calmettes

Status: Unknown

Conditions: Acute Lymphoid Leukemia; Leukemia, Myeloid, Acute

Treatments: Other: Blood sample; Other: Electrocardiogram

Study type: Interventional

Funder types: Other

Identifiers

NCT02345915

LEA-JA-IPC 2014-005

Details and patient eligibility

About

Taking into account the specificities of adolescent and young adult cancer patients led agencies (in particular the French National Cancer Institute INCa, through the last Cancer Plan), to initiate projects targeting this population. Acute leukemia is among the most common cancers in adolescents and young adults. Recent therapeutic advances now allow hope for a cure in about 50% of this population. The issue of post-cancer is therefore of particular importance for young adults with cancer. Our aim is to establish the health determinants in young adult leukemia survivors and to compare the frequency of these effects and their explanatory factors to the data collected in children or adolescent leukemia survivors program (LEA). 90 patients followed up at the Institut Paoli-Calmettes cancer center and Nice University Hospital have been identified and would be included in this study.Collected data will include information on the initial disease and its treatments, physical sequelae (fertility, thyroid function, heart function, visual function, secondary tumors, viral infections, lung function, bone metabolism, iron metabolism, metabolic syndrome, osteonecrosis, alopecia ... ), quality of life, social and occupational integration and relationship with care system.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 30 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Young adult (18-40 years) Leukemia survivor, in complete remission.
• Acute leukemia diagnosed since January 1980 .
• Patient Affiliated to social security or beneficiary
• Signed Informed Consent prior to any screening procedures

Exclusion criteria

• Emergency
• Patient unable to abide by the study protocol (for geographical, social or psychological reasons)

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

90 participants in 1 patient group

Young adult acute leukemia-survivor

Other group

Treatment:

Other: Blood sample

Other: Electrocardiogram