Evaluation of Alternative Transfusion Triggers in Hemodynamically Stable, Non-Ventilated Cancer Patients

Ardak Arynov

Status: Completed

Conditions: Anemia; Alternative Physiological Transfusion Triggers; Hemoglobin; Blood Transfusion; Cancer

Treatments: Procedure: Red blood cell transfusion

Study type: Observational

Funder types: Other

Identifiers

NCT06952361

KazIOR-ALTTRANS-2019

Details and patient eligibility

About

This is a prospective, single-center observational study conducted at the Kazakh Institute of Oncology and Radiology. The study included 107 clinically stable adult patients with cancer who required red blood cell transfusion based on a restrictive hemoglobin threshold. The aim of the study was to evaluate alternative physiological indicators of transfusion need and effectiveness. Measurements included oxygen extraction ratio (O₂ER), central venous oxygen saturation (ScvO₂), partial pressure of oxygen in central venous blood (PvO₂), arterio-venous oxygen difference (A-VO₂diff), lactate, and veno-arterial carbon dioxide difference (ΔCO₂). These parameters were assessed before and one hour after transfusion. For data analysis, patients were stratified into two groups based on their baseline O₂ER (≤35.4% and >35.4%) to evaluate whether higher O₂ER is associated with more pronounced physiological response to transfusion.

Enrollment: 107 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult cancer patients (age 18 years or older)
• Hemodynamically stable
• Not requiring any form of respiratory support
• Presence of a central venous catheter inserted into the superior vena cava

Exclusion criteria

• Hemodynamic instability requiring inotropic or vasopressor support
• Active bleeding
• Shock of any etiology
• Patient refusal to participate in the study
• Hematological malignancies
• Age under 18 years
• Pregnancy

Trial design

107 participants in 1 patient group

Cancer Patients with Anemia Receiving RBC Transfusion

Description:

This group includes clinically stable, non-ventilated adult oncology patients with anemia who received red blood cell transfusion at the Kazakh Institute of Oncology and Radiology. All participants were monitored for physiological parameters-including O₂ER, ScvO₂, PvO₂, A-VO₂diff, lactate, and ΔCO₂-before and one hour after transfusion.

Treatment:

Procedure: Red blood cell transfusion