Evaluation of an Anti-TREM-1 Treatment on an ex Vivo Human Intestinal Model (TIME)

Inotrem

Status: Enrolling

Conditions: Inflammatory Bowel Diseases

Treatments: Other: Additional biopsies and blood samples

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT06580418

TIME

Details and patient eligibility

About

TIME is an observational study performed on UC and CD patients under endoscopic surveillance for monitoring the clinical activity of their disease.

The main objective of the study is to confirm the therapeutic potential of TREM-1 in inflammatory bowel disease.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients between 18 and 60 years
• Signed informed consent
• Ulcerative colitis (UC) patients with active disease
• Crohn's disease (CD) patients with active disease

Exclusion criteria

• UC or CD patients in remission
• Patients between 18 and 60 years without informed consent

Trial design

40 participants in 2 patient groups

Ulcerative colitis (UC)

Description:

20 patients with moderate to severe UC under endoscopic surveillance for their disease

Treatment:

Other: Additional biopsies and blood samples

Crohn's Disease (CD)

Description:

20 patients with moderate to severe CD under endoscopic surveillance for their disease

Treatment:

Other: Additional biopsies and blood samples