Evaluation of Analgesia Nociception Index (ANI) During Propofol/Remifentanil and Sevoflurane/Remifentanil Anesthesia

University Hospital Schleswig-Holstein (UKSH)

Status: Unknown

Conditions: General Anaesthesia

Treatments: Procedure: tetanic stimulation

Study type: Observational

Funder types: Other

Identifiers

NCT01522508

ANI-134-1

Details and patient eligibility

About

The aim of this prospective randomized study was to evaluate the ability of the new Analgesia Nociception Index ANI, derived by heart rate variability, to detect painful stimulation during either propofol or sevoflurane anesthesia and changing remifentanil concentrations.

Full description

Monitoring Antinociception during general anesthesia is still a big challenge in the field and has not become clinical routine yet. Recently, for the Surgical Pleth Index SPI a benefit for the patient in terms of reduction of remifentanil use, less unwanted effects and shorter recovery from anesthesia was reported. However, there are new variables like the ANI that are developed to measure antinociception during anesthesia.

In the present study the investigators want to evaluate, whether ANI detects a painful tetanic stimulus during general anesthesia using propofol or sevoflurane and different concentrations of remifentanil.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age between 18- 65 years,
• ASA physical status I or II,
• elective surgery in general anesthesia planned,
• written informed consent

Exclusion criteria

• pregnancy,
• history of cardiac arrhythmia,
• presents of any neuromuscular or neurologic disease,
• use of CNS-active medication or abuse of alcohol/illicit drugs -

Trial design

50 participants in 2 patient groups

propofol/remifentanil

Description:

patients receive standardized propofol and changing remifentanil concentrations

Treatment:

Procedure: tetanic stimulation

sevoflurane/remifentanil

Description:

patients receive standardized sevoflurane and changing remifentanil concentrations

Treatment:

Procedure: tetanic stimulation