Evaluation of Anti-mullerian Hormone Levels as Predictive of IVF Outcomes in Women Over 38 Years Old

Reproductive Medicine Associates of New Jersey

Status: Completed

Conditions: IVF Patients Over 38 Years Old; Inhibin B Levels; AMH Levels

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT01219387

RMA-00-09

Details and patient eligibility

About

The present study is designed to evaluate the basal serum levels of anti-mullerian hormone (AMH) and inhibin B as early predictors of ovarian response, implantation rate, and pregnancy rate in women 38 years old or older that are undergoing an IVF cycle.

Full description

Specifics aims are: a) to describe AMH and inhibin levels on day 3 previous to ART cycle; b) to analyze the association between these hormone levels and the retrieved metaphase II oocytes quantity; c) to analyze the association between these hormone levels and quality embryo score d) to analyze the association between these hormone levels and the number of gestational sacs per transferred-embryo (implantation rate); e) to analyze the association between these hormone levels and the pregnancy rate; f) to make a prediction model for pregnancy rate by using a multivariable regression analysis.

Patient participation includes signing the consent and having additional tubes of blood drawn at a regularly scheduled blood draw. This blood is used to run the study tests (AMH and inhibin levels).

Enrollment: 300 patients

Sex: Female

Ages: 38 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Women 38 years old or older at the time of initiating treatment

Exclusion criteria

1. Uterine disease: malformation, septum, submucosal myomas, endometrial polyps Advanced endometriosis with endometrioma (s)
2. No uterus
3. Single ovary