Evaluation of Aortic Aneurysms With Focus on Wall Stress and Wall Rupture Risk

University of Zurich (UZH)

Status: Unknown

Conditions: Aortic Aneurysm

Treatments: Other: CT-acquisition

Study type: Observational

Funder types: Other

Identifiers

NCT02800876

KEK-ZH-Nr. 2015-0156

Details and patient eligibility

About

Retrospective study to evaluate the impact of computational wall stress analysis based on computed tomography (CT) of ruptured and not-ruptured aortic aneurysms as an additional predictor for rupture with dedicated software.

Full description

In patients with known aortic aneurysm who received clinically indicated CT during a time period from 01/2004-12/2013 the CT data was evaluated with dedicated software, A4clinics, VASCOPS GmbH, Graz, Austria. The following parameters will be evaluated: exterior and luminal diameter, intraluminal thrombus (ILT) thickness, vessel-, luminal- and intraluminal thrombus volume, peak wall stress (PWS), peak wall rupture risk (PWRR), von Mises-stress and rupture risk-index in the ILT.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Clinical indicated CT data from patients with known aortic aneurysms.

Clinical indication was:

• Follow up CT examination by known aortic aneurysm
• Patient with known aortic aneurysm with new acute clinical symptoms
• Patients with clinical suspicion of aortic aneurysm

Exclusion criteria

• known exclusion criteria for CT examination as known allergy to iodine or contrast media
• known pregnancy

Trial design

150 participants in 4 patient groups

asymptomatic not ruptured aneurysm

Description:

Patients with asymptomatic not ruptured aortic aneurysms greater than 3 cm who received a clinical indicated CT

Treatment:

Other: CT-acquisition

symptomatic not ruptured aneurysm

Description:

Patients with symptomatic aortic aneurysms greater than 3 cm who received a clinical indicated CT

Treatment:

Other: CT-acquisition

symptomatic ruptured aneurysm

Description:

Patients with symptomatic ruptured aortic aneurysms greater than 3 cm who received a clinical indicated CT

Treatment:

Other: CT-acquisition

patients with small aneurysms

Description:

Patients with small aortic aneurysms approximately 5.5 cm, ruptured and not ruptured, who received a clinical indicated CT

Treatment:

Other: CT-acquisition