Evaluation of Astaxanthin Properties on Anti-fatigue

China Medical University

Status: Completed

Conditions: Healthy Volunteer

Treatments: Other: Astaxanthin (AST trial); Other: Placebo (Placebo trial)

Study type: Interventional

Funder types: Other; Other U.S. Federal agency

Identifiers

NCT06593535

CMUH111-REC3-081

Details and patient eligibility

About

Ten young, healthy, physically active male college students were crossed over for AST or placebo supplements randomized into placebo or AST trials and orally consumed placebo or AST (28 mg/d) supplements for four days. Short-term AST supplementation enhanced endurance performance and effectively reversed cycling challenge-induced muscle damage and lipid peroxidation.

Full description

AST is composed of two β-ionone ring systems that are linked by a polyene chain and contain oxygenated keto and hydroxyl moieties, which are responsible for its powerful antioxidant activity. AST has been shown to have numerous health benefits in humans, including improved antioxidant and inflammatory status under different stress conditions. Therefore, this study will explore AST supplement to improve exercise-induced muscle damage and/or physiological anomalies in adults. Ten physically active male adults were randomized into placebo or AST trials and consumed placebo or AST (28 mg/d) supplements orally for 4 days. On day-4, participants performed an exhaustive cycling challenge at 75% V̇O2max, and the time to exhaustion (TTE) was recorded. Blood and gaseous samples were collected before, during, and immediately after cycling to determine changes in muscle damage, inflammation, oxidative stress, and substrate utilization.

Enrollment: 10 patients

Sex: Male

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Recruit people who are healthy are 20-40 years male and have exercise habits in college students

Exclusion criteria

• Have smoking and drinking habits.
• Those who have implanted artificial joints in the past six months and have had recent surgery.
• People who feel unwell due to other reasons during the experiment.
• Take any drugs or Nutrition supplements in the past 3 months.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

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10 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

containing edible yellow No. 4, edible yellow No. 5, sucrose, silica, talc, oxidized starch, gelatin, magnesium stearate, and palm wax.

Treatment:

Other: Placebo (Placebo trial)

Other: Astaxanthin (AST trial)

Astaxanthin (AST)

Experimental group

Description:

Each capsule containing 4 mg of AST

Treatment:

Other: Placebo (Placebo trial)

Other: Astaxanthin (AST trial)