Evaluation of Attenuation Correction Accuracy in Positron Emission Tomography-Magnetic Resonance Imaging (PET-MRI)

The Washington University

Status: Terminated

Conditions: PET/CT

Treatments: Device: Positron Emission Tomography-Magnetic Resonance Imaging (PET-MRI)

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT03423407

201710134

1R01CA212148-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this research proposal is to establish a mechanism to develop tools that will allow the investigators to measure the impact of magnetic resonance (MR) acquisition correction sequences for attenuation correction on positron emission tomography (PET) quantitation accuracy.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Participant must be ≥ 18 years of age
• Participant can be a male or a non-pregnant female.
• Successful completion of MRI screening form
• Participant must have undergone a PET/CT examination with injection of a standard dose of 18F-fluorodeoxyglucose (FDG) or other PET tracer with a half-life greater than one hour either for clinical or research purposes within 3 hrs of the proposed PET-MRI examination.
• Participant will be fully informed and has personally signed and dated the written Informed Consent and Health Insurance Portability and Accountability Act (HIPAA) provisions

Exclusion criteria

• Subjects for whom exposure to a strong magnetic field would be a health risk (e.g., subjects with cardiac pacemakers or non-MR compatible metallic implants)
• Women who are pregnant.
• Subjects who require sedation to participate will be excluded.
• Patient/participant has a medical condition which in the judgment of the investigator might make supine positioning for the duration of the scan unsafe, such as (but not limited to) congestive heart failure or significant pulmonary disease.

Trial design

30 participants in 1 patient group

PET/MR

Description:

* Participants will be scanned on a PET-MRI scanner which is FDA-approved and will operate within FDA-approved guidelines. * Participants will be asked to lie still within the scanner for up to 90 minutes

Treatment:

Device: Positron Emission Tomography-Magnetic Resonance Imaging (PET-MRI)