Evaluation of Biological Markers of Mesenteric Ischemia During an Ultra-trail (ISKETRAIL)

University Hospital, Clermont-Ferrand

Status: Completed

Conditions: Ultra-trail Participation

Treatments: Biological: Blood analysis

Study type: Observational

Funder types: Other

Identifiers

NCT03205098

2015-A00470-49 (Other Identifier)

CHU-340

Details and patient eligibility

About

To assess the evolution of biological markers of mesenteric ischemia during ultratrail.

Full description

During physical exercise, increased sympathetic nervous system activity redistributes blood flow from splanchnic organs to working muscles. With prolonged duration and / or intensity, the splanchnic blood flow can be reduced by 80% or more. A severely reduced of splanchnic blood flow can frequently cause gastrointestinal ischemia. This ischemia associated with reduced vagal activity probably results in changes in motility and absorption.

High symptoms are reported in 40% of runners with reflux and heartburn in 15-20% of runners. The low symptoms have an incidence of about 70% in the long runs type ultra-trail.

Biological markers such as I-FABP have been shown to be useful in the diagnosis of mesenteric ischemia.

Enrollment: 200 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy Voluntary Subject
• Age > 18 years
• Written consent
• Subject affiliated to Social Security
• Medical certificate (mandatory to take part in the ultra-trail)

Exclusion criteria

• Refusal to participate
• Subject with legal protection (guardianship, trusteeship)

Trial design

200 participants in 1 patient group

Runners

Description:

To assess the evolution of biological markers of mesenteric ischemia during ultratrail.

Treatment:

Biological: Blood analysis