Evaluation of Biomarker Levels in Blood, Saliva and Gingival Fluid in Periodontitis

Yuzuncu Yıl University

Status: Unknown

Conditions: Periodontitis

Treatments: Other: No intervention was applied to the groups the samples will be collected in terms of the diagnosis (hopeless, periodontitis, gingivitis, healthy)

Study type: Observational

Funder types: Other

Identifiers

NCT04647123

: 06.06.2018/09

Details and patient eligibility

About

The aim of this study was to compare IMA, MDA, CAT, GSH and ADA levels in gingival crevicular fluid, serum and saliva of periodontally hopeless, periodontitis and gingivitis teeth with healthy control groups.

Full description

The research methodology was approved by the Van Yuzuncu Yıl University Clinical Research Ethics Committee. (Decision number: 06.06.2018/09).

The aim of this study is to compare Ischemia-modified albumin (IMA), malondialdehyde (MDA), Catalase (CAT), Glutathione (GSH) and Adenosine deaminase (ADA) levels in gingival crevicular fluid, serum and saliva of periodontally hopeless, periodontitis and gingivitis teeth with healthy control groups.

In this study, 25 periodontally healthy individuals (control group) and 25 individuals with various levels of periodontal disease in different teeth will be included.

Gingival crevicular fluid, saliva and blood samples will be taken from patients with periodontally healthy teeth without any treatment.

In patients diagnosed with periodontal disease, teeth will be divided into 3 subgroups as hopeless, periodontitis and gingivitis. In patients with a diagnosis of periodontal disease, saliva and blood samples will be taken twice, before and after the training of scaling and root planing, desperate tooth extraction, oral hygiene motivation.

Enrollment: 40 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Systemically healhty non-smokers non-pregnants -

Exclusion criteria

• Patients with systemic disease smokers pregnants

Trial design

40 participants in 4 patient groups

Hopeless teeth

Description:

The teeth that can not be treated periodontally and who are desperate for extraction will be included in this group.

Treatment:

Other: No intervention was applied to the groups the samples will be collected in terms of the diagnosis (hopeless, periodontitis, gingivitis, healthy)

Periodontitis

Description:

Teeth diagnosed with periodontitis will be included in this group.

Treatment:

Other: No intervention was applied to the groups the samples will be collected in terms of the diagnosis (hopeless, periodontitis, gingivitis, healthy)

Gingivitis

Description:

Teeth diagnosed with gingivitis will be included in this group.

Treatment:

Other: No intervention was applied to the groups the samples will be collected in terms of the diagnosis (hopeless, periodontitis, gingivitis, healthy)

Healthy

Description:

Teeth diagnosed with helthy will be included in this group.

Treatment:

Other: No intervention was applied to the groups the samples will be collected in terms of the diagnosis (hopeless, periodontitis, gingivitis, healthy)