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Evaluation of Blood Biomarkers as an Indicator of Postoperative Cognitive Dysfunction

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Seoul National University

Status

Unknown

Conditions

Postoperative Cognitive Dysfunction

Treatments

Diagnostic Test: Assessment of delirium
Diagnostic Test: Blood sampling for assessment of the level of D-Amino Acid Oxidase, D-serine and Serine in blood
Diagnostic Test: Neurocognitive test

Study type

Interventional

Funder types

Other

Identifiers

NCT04679259
30-2020

Details and patient eligibility

About

Postoperative cognitive dysfunction is defined as a cognitive decline arising after surgery. In the present study, the authors evaluate the level of D-Amino Acid Oxidase, D-serine and Serine in blood as an indicator of postoperative cognitive dysfunction after cardiac surgery.

Enrollment

149 estimated patients

Sex

All

Ages

50+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients scheduled for elective cardiac surgery

Exclusion criteria

  • MMSE <24
  • History of psychological or neurological diseases
  • Illiteracy

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

149 participants in 1 patient group

Cardiac surgical patients
Experimental group
Treatment:
Diagnostic Test: Neurocognitive test
Diagnostic Test: Blood sampling for assessment of the level of D-Amino Acid Oxidase, D-serine and Serine in blood
Diagnostic Test: Assessment of delirium

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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