Evaluation of Blood Biomarkers as an Indicator of Postoperative Cognitive Dysfunction

Seoul National University

Status: Unknown

Conditions: Postoperative Cognitive Dysfunction

Treatments: Diagnostic Test: Assessment of delirium; Diagnostic Test: Blood sampling for assessment of the level of D-Amino Acid Oxidase, D-serine and Serine in blood; Diagnostic Test: Neurocognitive test

Study type: Interventional

Funder types: Other

Identifiers

NCT04679259

30-2020

Details and patient eligibility

About

Postoperative cognitive dysfunction is defined as a cognitive decline arising after surgery. In the present study, the authors evaluate the level of D-Amino Acid Oxidase, D-serine and Serine in blood as an indicator of postoperative cognitive dysfunction after cardiac surgery.

Enrollment: 149 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients scheduled for elective cardiac surgery

Exclusion criteria

• MMSE <24
• History of psychological or neurological diseases
• Illiteracy

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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149 participants in 1 patient group

Cardiac surgical patients

Experimental group

Treatment:

Diagnostic Test: Neurocognitive test

Diagnostic Test: Blood sampling for assessment of the level of D-Amino Acid Oxidase, D-serine and Serine in blood

Diagnostic Test: Assessment of delirium