Evaluation of Blood Flow Characteristics in Glaucoma Using Optical Coherence Tomography Angiography (OCT-A).

Swiss Vision Network

Status

Terminated

Conditions

Glaucoma

Treatments

Device: Optical Coherence Tomography based Angiography

Study type

Observational

Funder types

Other

Identifiers

NCT02757677

GR-02

Details and patient eligibility

About

The investigators aim to evaluate the efficacy of the new Optical Coherence Tomography based Angiography (OCT-A) softwares in the diagnosis and management of glaucoma.

Enrollment

200 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Diagnosis of open angle glaucoma (OAG) including pseudo-exfoliative and pigmentary glaucoma.
Documented glaucomatous visual field damage (in the previous 12 months with mean defect (MD) > 2.0 dB)
Structural and/or functional glaucomatous damage
Have given written informed consent, prior to any investigational procedures

Exclusion criteria

Patients with allergy to corneal anesthetic
Patients not able to understand the character and individual consequences of the investigation
Participation in other clinical research within the last 4 weeks
Other diseases that may cause visual field loss or optic disc abnormalities
Refractive error of > +3.00D or < -7.00D

Trial design

200 participants in 3 patient groups

Longitudinal arm

Description:

Evaluate optic nerve head blood flow using the new OCT-A software in surgically and medically treated glaucoma patients and in different types of glaucoma

Treatment:

Device: Optical Coherence Tomography based Angiography

24-h Intraocular pressure (IOP) arm

Description:

Evaluate the correlation between circadian IOP changes and optic nerve head blood flow using the new OCT-A software

Treatment:

Device: Optical Coherence Tomography based Angiography

Surgery arm

Description:

Evaluate blood flow using the new OCT-A software in surgically treated glaucoma patients

Treatment:

Device: Optical Coherence Tomography based Angiography