Evaluation of Bone Metabolism Biomarkers in Periodontal Diseases

Necmettin Erbakan University

Status

Completed

Conditions

Periodontal Diseases

Treatments

Diagnostic Test: ELISA

Study type

Interventional

Funder types

Other

Identifiers

NCT05702892

Ummuhan.tekinatay

Details and patient eligibility

About

This study evaluates the levels of biomarkers associated with bone metabolism in patients with different periodontal conditions.

Full description

Background: In this study, the levels of bone metabolism markers found in the saliva of individuals with different periodontal conditions were compared and the relationship of these markers with periodontal status was examined.

Method: A total of 60 individuals, 20 with periodontitis (P), 20 with gingivitis (G), and 20 with periodontal healthy (S), were included in the study. Periodontal clinical parameters (plaque index, gingival index, bleeding on probing, clinical attachment level and probing pocket depth) and saliva samples were obtained from the individuals. Bone metabolism biomarker (necrotizing factor (TNF)-α, osteoprotegerin (OPG), nuclear factor kappa-β receptor activator ligand (RANKL) and sclerostin) levels in saliva samples were evaluated by enzyme-linked immunosorbent assay (ELISA).

Enrollment

60 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

18-65 years old.
not having any systemic disease that may affect periodontal status
not smoking and alcohol use
volunteer to participate in the study

Exclusion criteria

periapical pathologies;
resulting from orthodontics and occlusion extreme forces, including mechanical forces;
chronic high-dose steroid therapy;
radiation or immunosuppressive therapy;
pregnancy;
breastfeeding;
allergy or sensitivity to any medication.
Periodontal therapy or drug therapy for at least 6 months of study participants