Evaluation of Brain Damage Resulting From Carotid Endarterectomy With Xenon Anesthesia

Centre Hospitalier Universitaire de Nīmes

Status

Completed

Conditions

Carotid Endarterectomy

Treatments

Drug: Anesthesia with Xenon

Drug: Standard anesthesia

Study type

Interventional

Funder types

Other

Identifiers

NCT01404819

2011-002551-33 (EudraCT Number)

LOCAL/2011/JRGC

Details and patient eligibility

About

The objective of this study is to show that, in patients undergoing carotid endarterectomy, brain damage, assessed by the determination of S100B before removing the clamp, is less severe with a balanced anesthesia consisting of remifentanil combined with Xenon (experimental arm) compared with remifentanil anesthesia associated with propofol (reference arm).

Enrollment

86 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

The patient must have given his/her informed and signed consent
The patient must be insured or beneficiary of a health insurance plan
Patients with American Society of Anesthesiology (ASA) scores of 1 to 4
Patient schelduled for carotid endarterectomy

Exclusion criteria

The patient is participating in another study
The patient is in an exclusion period determined by a previous study
The patient is under judicial protection, under tutorship or curatorship
The patient refuses to sign the consent
It is impossible to correctly inform the patient
The patient is pregnant
The patient is breastfeeding
The patient has a contra-indication for a treatment necessary for this study
The endarterectomy does not require a shunt
ASA score of 5
Patient presenting with symptomatic gastric-oesophagien reflux
Patient has neuro-endocrine cancer
Patient has hypersensivity to one of the following substances: propofol, remifentanil, celocurine, cisatracurium, rocuronium, senon, paracetamol, tramadol
Patient suffering from obstructive respiratory insufficiency (chronic obstructive pulmonary disease, asthma)
Patient with coronary disease with severely altered cardiac function
High intracranial pressure
Patient requiring high concentrations of oxygen (SpO2 < 92% normal air)
Patient with neuro-sensorial deficit that, in the absence of a prothesis, prevents reading, writing, or responding to simple orders
Patient suffering from myopathy or recent rhabdomyolysis
Patient with psychiatric pathology or chronic alcohol consumption or consumption of another substance that interferes with understanding
Lack of contraception for women of child-bearing age
History of or suspected malignant hyperthermia
Patients with liver damage, jaundice, unexplained fever or eosinophilia after administration of a halogenated anesthetic
Patient has undergone a recent multiple trauma (<1 month)
Patient who received general anesthesia within the past 7 days