Evaluation of Brain MRI and Clinical Characteristics of Adolescents With Bipolar Disorder and Children of Parents With Bipolar Disorder

Turkish Psychiatry Association

Status: Unknown

Conditions: Bipolar Disorder

Study type: Observational

Funder types: Other

Identifiers

NCT01678989

4946498

Details and patient eligibility

About

Genetic transition is important in the etiology of bipolar disorder (BD). So, evaluation of children of BD parents and diagnosed with and BD children whether or not brain has affected zones. These groups were compared to healthy controls and whether or not the mental health of children is influenced will be evaluated by the clinical investigation.

Full description

MRI studies in children at risk of BD, our understanding of the neurobiology of BD and abnormalities in the studied regions, regions that predispose to the development of our understanding of PBB will shed light on the etiology of the disorder. In this study, the cranial MRI findings and clinical features in adolescents with bipolar disorder and the same age and sex matched children who have parents with BD and healthy controls were investigated. Since there is few studies that evaluate these three groups, there is a need to increase our knowledge on this issue.

Enrollment: 60 estimated patients

Sex: All

Ages: 12 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Children with BD between the ages of 12-18
• Parents with BD who have children between the ages of 12-18
• Healthy children whose parents do not have BD
• Patients who does not have mental or organic disability to answer the questions
• Graduated from primary school

Exclusion criteria

• Patients who have mental or organic disability to answer the questions
• Patients who have a history of any chronic disease which is likely to affect the central nervous system
• Patients who have a contraindication for any first application for Magnetic Resonance Imaging (MRI)

Trial design

60 participants in 3 patient groups

Patient group

Description:

Children with BD, (20 children) 12-18 year-old who agreed to participate in the study will be established.

Risk group

Description:

Twenty healthy children of 12-18 years old who have mothers and/or fathers who previously assessed by an adult psychiatrist and diagnosed as BD according to DSM-IV diagnostic criteria, and who agreed to participate in the study. The age and gender of the groups will be matched.

Healthy control group

Description:

Twenty participants between the ages of 12-18 who agree to participate in the study and whose family members do not have BD. The age and the gender of the groups will be matched.