Evaluation of Brain Waste Clearance Pathways Using Magnetic Resonance Imaging in Pediatric Patients With White Matter Diseases

IRCCS Eugenio Medea

Status: Active, not recruiting

Conditions: Perivascular Disease; Pediatric Disorder; White Matter Disease; Glymphatic System

Treatments: Diagnostic Test: Magnetic resonance imaging

Study type: Observational

Funder types: Other

Identifiers

NCT06335004

926

Details and patient eligibility

About

The dilation of perivascular spaces can be the result of various etiopathogenetic processes. White matter atrophy can cause enlargement of these perivascular spaces (PVS) but also obstruction of fluid drainage systems (interstitial fluid, ISF) and metabolites, as evidenced by some recent studies. Focal stagnation of liquids and deposition of toxic material induce tissue hypoxia and neuroglial dysfunction. Dilation of PVS can be associated with changes in white matter and microhemorrhages. We want to study these etiopathogenetic phenomena by implementing specific MRI methods.

Full description

Primary objective: the quantification of indirect magnetic resonance markers of altered waste drainage systems using validated scales in patients with white matter disease. Secondary objective: the evaluation of white matter alterations in relation to the known anatomical glymphatic pathways by analyzing both structural and diffusion data.

Enrollment: 100 estimated patients

Sex: All

Ages: 9 months to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with and without white matter disease
• patients willing to participate in research with signed consent form
• no age limit (results will be age matched)

Exclusion criteria

• unwilling to participate in research

Trial design

100 participants in 2 patient groups

Patients with white matter disease/healthy subjects

Description:

Patients with white matter disease due to genetic or acquired causes. MRI with or without intravenous gadolinium will be performed

Treatment:

Diagnostic Test: Magnetic resonance imaging

Patients with no white matter disease

Description:

Patients undergoing MRI with or without gadolinium for clinical diagnostic purposes, with no known white matter disease.

Treatment:

Diagnostic Test: Magnetic resonance imaging