Evaluation of Breathing Effort in Spontaneously Breathing Subjects

Czech Technical University in Prague

Status: Unknown

Conditions: Healthy

Treatments: Device: Breathing through a system with adjustable flow resistance

Study type: Interventional

Funder types: Other

Identifiers

NCT04051645

iWoBvsiPTP

Details and patient eligibility

About

The aim of the research project is to evaluate the breathing effort using the Work of Breathing (WoB) and Pressure-Time Product (PTP) parameters, depending on the increasing flow resistance. The research project is concerned with assessing the increased (imposed) breathing effort using the Work of Breathing (iWoB) and the Pressure-Time Product (iPTP).

The main hypothesis tested is the differential effect of flow resistance on iWoB and iPTP parameters in spontaneous breathing of healthy probands.

Full description

Due to the different calculation of iWoB and iWoB, these parameters may be affected at higher flow resistance values. The proposed experiment will be used to compare iWoB and iPTP obtained during spontaneous breathing to healthy subjects.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy males and females > 18 and < 40 years old
• Signed informed consent has been obtained

Exclusion criteria

• Respiratory disease
• Pregnancy
• Cardiovascular disease
• Diabetes mellitus

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Breathing through a system with adjustable flow resistance

Experimental group

Description:

During the experiment, the volunteers will breathe through ten adjustable flow resistances and their work of breathing will be measured.

Treatment:

Device: Breathing through a system with adjustable flow resistance