Evaluation of Cardiotoxic Effects of Bortezomib

Oregon Health & Science University (OHSU)

Status: Completed

Conditions: Heart Failure, Systolic; Multiple Myeloma; Cardiotoxins

Treatments: Drug: Bortezomib

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT02026505

IRB00010254

Details and patient eligibility

About

The purpose of this study is to learn more about how a drug commonly used to treat multiple myeloma can affect the heart.

In this study, the investigators will learn whether a drug called how a drug (called bortezomib, or Velcade) receive for multiple myeloma affects the heart. Bortezomib is part of the standard treatment and its effects on multiple myeloma is not being studied here.

The investigators want to learn whether damage occurs to the heart after taking bortezomib for multiple myeloma, whether it is reversible, and we can predict damage to the heart before it occurs.

Enrollment: 11 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of multiple myeloma
• have a treatment plan involving greater than 4 cycles of bortezomib-based chemotherapy

Exclusion criteria

• pre-existing history of left ventricular systolic dysfunction
• congestive heart failure
• coronary artery disease
• significant valvular heart disease
• cardiac arrhythmias
• estimated glomerular filtration rate <30 mL/min/1.73m2

Trial design

11 participants in 1 patient group

Multiple Myeloma, Bortezomib

Treatment:

Drug: Bortezomib