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Serum HBV DNA is a referent but insufficient marker of therapeutic follow-up in chronic hepatitis B treatment. Intra hepatic cccDNA disappearance reflects HBV eradication in the liver.
Intra lymphocyte cccDNA could be a new marker of HBV eradication after treatment.
The major interest of this marker is that it can be measured by a simple blood test instead of a liver biopsy.
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Studying intra lymphocyte and blood cccDNA: before inclusions, D0 then each month during the first three months each three months during treatment and follow-up.
Viral kinetics:Before inclusions, at D0, then monthly till the end of treatment and follow-up: Evolution of quantitative viraemia in serum Evolution of quantitative viraemia in circulating lymphocytes Evolution of quantitative viraemia in total blood
Studying viral genotypes
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Data sourced from clinicaltrials.gov
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