Evaluation of Chronic Liver Disease Condition and Transplant Prognosis Assisted by Eye Biological Parameters

Sun Yat-sen University

Status: Enrolling

Conditions: Liver Cirrhoses; Liver Transplantation; Diagnostic Techniques, Ophthalmological

Treatments: Diagnostic Test: Ophthalmic examination; Diagnostic Test: General Condition Examination

Study type: Observational

Funder types: Other

Identifiers

NCT06756009

2021KYPJ148

Details and patient eligibility

About

This study investigates the correlation between ocular biological characteristics and overall conditions before and after liver transplantation by collecting ocular biological characteristics. Explore whether it is possible to construct a clinical prediction model for liver transplantation by incorporating ocular biometric features, in order to optimize disease management before and after liver transplantation.

Full description

This study is a bidirectional cohort study, which retrospectively analysed data from a prospective database to construct a model, and prospectively collected patient information from preoperative to postoperative for model improvement and validation.

Enrollment: 500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Age greater than or equal to 18 years old;
2. Late stage liver disease patients waiting for liver transplantation treatment, as well as patients with varying degrees of cirrhosis;
3. Can collect complete basic demographic information, liver function blood test indicators, liver pathology and imaging examination results;
4. Can cooperate with eye OCT, OCTA and other examinations, and obtain qualified examination parameters;
5. Voluntarily follow the clinical trial protocol and sign the informed consent form.

Exclusion criteria

1. History of other organ transplant surgeries;
2. History of intraocular laser treatment, medication injection, and surgery;
3. History of high myopia, glaucoma, and retinal choroidal related eye diseases;
4. History of major systemic diseases other than liver disease;
5. Individuals whose overall body and eye conditions cannot cooperate with eye examinations.

Trial design

500 participants in 3 patient groups

preoperative group

Description:

Registered liver transplant patients from preoperative to postoperative follow-up

Treatment:

Diagnostic Test: General Condition Examination

Diagnostic Test: Ophthalmic examination

Simple postoperative group

Description:

Follow up from after liver transplantation

Treatment:

Diagnostic Test: General Condition Examination

Diagnostic Test: Ophthalmic examination

Healthy control group

Description:

Healthy individuals without liver disease

Treatment:

Diagnostic Test: General Condition Examination

Diagnostic Test: Ophthalmic examination