Evaluation of Circulating Osteogenic Factors in Trauma Patients (BMP-9)

Centre de recherche du Centre hospitalier universitaire de Sherbrooke

Status: Terminated

Conditions: Healthy; Spinal Trauma; Cranial Trauma; High Velocity Fracture

Study type: Observational

Funder types: Other

Identifiers

NCT01433536

MOP-115149 (Other Grant/Funding Number)

10-100

Details and patient eligibility

About

Bone fractures in traumatic brain-injured and spinal cord-injured patients often heal faster than in other patients. However, such patients are also occasionally prone to bone formation in soft tissues such as muscle. This process is called heterotopic ossification and tends to occur around joints. Patients with heterotopic ossification often suffer from complications such nerve compression, ankylosis, chronic pain, osteoporosis, and infections. Loss of movement can also interfere with function and the quality of life of patients already experiencing difficulties associated with their trauma. Positioning, transfers, and hygiene become difficult and even impossible, which worsens the loss of autonomy.

Previous research has suggested that an osteoinductive factor (which has the capacity to induce the formation of bone) may be released into the bloodstream following a head or spinal cord injury. The investigators laboratory has shown that a growth factor called BMP-9, when injected into a damaged mouse muscle, has the ability to cause strong ossification in damaged muscle. The investigators would like to find out whether the levels of BMP-9 and/or its receptor (which is called ALK1) increase after traumatic brain and spinal cord injuries that occur at the same time as serious orthopaedic traumas.

The main goal of the investigators study is thus to determine whether BMP-9 levels increase in the serum of trauma patients.

Enrollment: 40 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• cranial trauma with Glasgow =< 8
• spinal trauma with ASIA A, B, C
• high-velocity fracture of femur, tibia, pelvis

Exclusion criteria

• brain dead
• pathological fractures (cancer, osteoporosis)
• blood transfusion received
• pregnancy

Trial design

40 participants in 6 patient groups

cranial trauma and fracture

Description:

Individuals presenting a cranial trauma that are classified at equal to or less than 8 on the Glasgow scale, combined with a fracture to the femur, tibia, or pelvis resulting from a high-velocity impact

cranial trauma

Description:

Individuals presenting a cranial trauma that are classified at equal to or less than 8 on the Glasgow scale

spinal trauma with fracture

Description:

Individuals presenting a spinal fracture that are classified with an ASIA score of A, B, or C, combined with a fracture to the femur, tibia, or pelvis resulting from a high-velocity impact

spinal trauma

Description:

Individuals presenting a spinal fracture that are classified with an ASIA score of A, B, or C

high velocity fracture, inferior limb

Description:

Individuals that present a fracture to the femur, tibia, or pelvis resulting from a high-velocity impact

Control

Description:

Healthy individuals