Evaluation of Circulating Tumor DNA as a Theranostic Marker in the Management of Glioblastomas. (Bi-GLAM)

Centre Hospitalier Universitaire, Amiens

Status: Terminated

Conditions: Glioblastoma; Molecular Disease

Treatments: Other: Correlation between molecular anomalies of the primary tumor and circulating tumor DNA

Study type: Interventional

Funder types: Other

Identifiers

NCT03115138

PI2015_843_0029

Details and patient eligibility

About

Glioblastomas (GBM) are rare tumors of poor prognosis and their treatment is based on surgery followed by radiochemotherapy. Clinical and imaging evaluation is not always straightforward: the more or less complete surgery, the pseudo-progression after radiochemotherapy, the radionecrosis, the diagnosis of the relapse and the follow-up under anti-angiogenic can pose problems Clinicians and radiologists. Accessibility to a plasma tumor molecular marker would greatly facilitate the follow-up of these patients.

It is now established for many cancers that circulating tumor DNA (cTNA) has the same molecular abnormalities as those identified in the primary tumor cells. Numerous studies have shown the prognostic value and diagnosis of the exploration of cDNA.

Enrollment: 19 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with grade IV glial tumor (glioblastoma according to WHO criteria) for which an indication of surgical excision with radiochemotherapy was chosen at a specialized multidisciplinary meeting of neuro-oncology at the CHU Amiens-Picardy.

• Patients should:

  • be able to be followed at the CHU of Amiens throughout their treatment,
  • be at least 18 years of age,
  • be informed (or trusted) of the conditions and objectives of the study,
  • having given their free and informed consent in writing,
  • have a life expectancy of more than 6 months,
  • be affiliated to a social security scheme.

Exclusion criteria

• Patients with recurrent tumors.
• Patients supported for another histology.
• Medical, psychological or social conditions that do not allow for proper understanding of the procedures inherent in the study.
• Patients under tutelage, curatorship.

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

19 participants in 1 patient group

Patients with glial tumor

Other group

Treatment:

Other: Correlation between molecular anomalies of the primary tumor and circulating tumor DNA