Evaluation of Cissus Verticillata L. Infusion in Controlling Type 2 Diabetes

Federal University of Paraíba

Status and phase: Completed; Phase 2; Phase 1

Conditions: Diabetes

Treatments: Other: medicinal plant infusion; Drug: glibenclamide

Study type: Interventional

Funder types: Other

Identifiers

NCT01145534

UFPB-0346

Details and patient eligibility

About

The purpose of this study was to investigate whether the infusion of a medicinal plant (Cissus verticillata L.) would be effective in reducing glucose levels in blood and saliva of type 2 Diabetes patients.

Full description

Type 2 diabetes mellitus is regarded as one of the most prevalent disease of the adult population. In many developing countries, this condition is regarded as major public health problem. Type 2 diabetes is a metabolic disorder characterized by high blood glucose related with a condition of insulin resistance and relative insulin deficiency. As Diabetes progresses, medications are necessary to control glucose levels.

The aim of this study was to investigate whether the infusion of a medicinal plant (Cissus verticillata L.) would be as effective as a regular drug (glibenclamide) in reducing glucose levels in blood and saliva of type 2 Diabetes patients. Several medicinal plants have been used as potential medication for controlling glucose levels in Diabetes patients. Few studies have explored this effect related to Cissus verticillata L.infusion, though it has been indicated by folk medicine of some Latin American countries.

Enrollment: 15 patients

Sex: All

Ages: 30 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• subjects of 30 up to 80 years of age
• positive diagnostic for type 2 diabetes mellitus (blood glucose level above 126 mg/dL)
• patients that signed the informed consent

Exclusion criteria

• patients with renal and hepatic disfunction,
• patients with cardiac problems or other systemic alterations (allergies, pulmonary and gastrointestinal problems)
• pregnant women

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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15 participants in 2 patient groups

Glibenclamide

Active Comparator group

Description:

Patients used 5 mg glibenclamide daily for 60 days

Treatment:

Drug: glibenclamide

Experimental

Experimental group

Description:

Patients ingested the infusion of Cissus verticillata L. prepared as 1 g in 150 mL of hot water for 10 min. This was done daily for 60 days

Treatment:

Other: medicinal plant infusion