Evaluation of Clinical and Genetic Modifiers of Long-term Survival in Heart Failure

Tongji Hospital

Status: Unknown

Conditions: Heart Failure

Treatments: Other: No intervention

Study type: Observational

Funder types: Other

Identifiers

NCT03461107

TJ-HF-ARB

Details and patient eligibility

About

The purpose of this study is to evaluate the beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade in patients with chronic heart failure.

Enrollment: 2,500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. 18 years of age or older;
2. Patients are required to have chronic heart failure (NYHA II-IV) with a left ventricular ejection fraction lower than 40%;
3. Patients are voluntary and signed informed consent.

Exclusion criteria

1. Pregnant women or plan to;
2. Participate in any drug clinical trials within 3 months;
3. Serious neurological disease (Alzheimer's disease, Parkinson syndrome, progressive lower limbs or deaf patients);
4. Previous history of cancer or tumor, or pathological examination confirmed precancerous lesions;
5. Patients refused to comply with the requirements of this study to complete the research work;
6. According to the researchers, patients can not complete the study or not to comply with the requirements of this study (because of the reasons for the management or other reasons).

Trial design

2,500 participants in 1 patient group

patients with heart failure

Treatment:

Other: No intervention